Abstract
Some new derivatives of 5-alkylaminomethyl-3-benzoyl-7-oxo-6,7-dihydroisoxazolo[4,3- d]pyrimidine [II-VI] and 7-amine substituted 3-benzoyl-5-phenylisoxazolo[4,3-d]pyrimidine [VIII-X] were synthesized. Preliminary results of pharmacological screening of compounds synthesized as [II-V,IX,X] have been presented.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Behavior, Animal / drug effects*
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Drug Design
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Electroshock
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Lethal Dose 50
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Male
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Mice
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Pentylenetetrazole / antagonists & inhibitors
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Psychotropic Drugs / chemical synthesis*
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Psychotropic Drugs / pharmacology
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Psychotropic Drugs / toxicity
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Pyrimidines / chemistry
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Pyrimidines / metabolism*
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Seizures / chemically induced
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Seizures / prevention & control*
Substances
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Psychotropic Drugs
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Pyrimidines
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Pentylenetetrazole