Synthesis and preliminary pharmacological assessment of derivatives of isoxazolo[4,3-d]pyrimidine. II

Acta Pol Pharm. 1994;51(4-5):355-8.

Abstract

Some new derivatives of 5-alkylaminomethyl-3-benzoyl-7-oxo-6,7-dihydroisoxazolo[4,3- d]pyrimidine [II-VI] and 7-amine substituted 3-benzoyl-5-phenylisoxazolo[4,3-d]pyrimidine [VIII-X] were synthesized. Preliminary results of pharmacological screening of compounds synthesized as [II-V,IX,X] have been presented.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Behavior, Animal / drug effects*
  • Drug Design
  • Electroshock
  • Lethal Dose 50
  • Male
  • Mice
  • Pentylenetetrazole / antagonists & inhibitors
  • Psychotropic Drugs / chemical synthesis*
  • Psychotropic Drugs / pharmacology
  • Psychotropic Drugs / toxicity
  • Pyrimidines / chemistry
  • Pyrimidines / metabolism*
  • Seizures / chemically induced
  • Seizures / prevention & control*

Substances

  • Psychotropic Drugs
  • Pyrimidines
  • Pentylenetetrazole