61 cases of the gastric cancers have been treated with Replenishing Qi and Invigorating Spleen (RQIS) combined with chemotherapy. The patients were divided into treated group and control group randomly, The results showed that: rate of the adverse effects, e.g. nausea, vomiting, anorexia, diarrhea etc. were higher in the chemotherapy used patients, combined treated groups were lower significantly (P < 0.01-0.001). Rate of chemotherapy completion was 95% in the treated group, 78% in control group, the difference was significant (P < 0.01). WBC and blood platelet were reduced in the treatment group and chemotherapy group, they were 30% and 45% respectively (P < 0.01). Superoxide dismutase was increased obviously (P < 0.01). It revealed that RQIS could scavenge the free radical potently. 60 cases of gastric cancers have been treated over 1 year, the survival rates of 1 year, 3 years, 5 years were 98.36%, 82.69%, 60.00% respectively after following up. Among them, survival rate of III stage patients was 57.14%. Animal experimental study showed that the inhibition rates of lung metastasis were 92.2% and 83.7% in mice B16 of RQIS groups. The difference was significant than that of control group. They could elevate the tolerance to chemotherapy in mice.