Prevalence of human astrovirus serotype 4: capsid protein sequence and comparison with other strains

Epidemiol Infect. 1995 Apr;114(2):385-91. doi: 10.1017/s0950268800058015.


Astrovirus serotype 4 has increased in relative prevalence in the Oxford, UK area in 1993. The structural gene of human astrovirus serotype 4 has been sequenced and the results indicate that this protein differs substantially from serotypes 1 and 2. In particular, conservation at the C terminus is greatly reduced. However, amino acid substitutions in this region show a strong conservation in character suggesting that structural or functional constraints operate in this region.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Capsid / chemistry*
  • Capsid / genetics
  • Genes, Viral
  • Humans
  • Mamastrovirus / chemistry*
  • Mamastrovirus / classification
  • Mamastrovirus / genetics
  • Molecular Sequence Data
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Serotyping
  • Viral Structural Proteins / genetics


  • Viral Structural Proteins

Associated data

  • GENBANK/Z33883