Gene clusters encoding the cytotoxic necrotizing factor type 1, Prs-fimbriae and alpha-hemolysin form the pathogenicity island II of the uropathogenic Escherichia coli strain J96

FEMS Microbiol Lett. 1995 Feb 15;126(2):189-95. doi: 10.1111/j.1574-6968.1995.tb07415.x.

Abstract

The uropathogenic Escherichia coli strain J96 (04:K6) is able to produce four adherence factors [P-fimbriae (pap and prs), F1C-fimbriae (foc) and Type 1-fimbriae (fim)], two alpha-hemolysins (hlyI and II) and the cytotoxic necrotizing factor type 1 (cnf1). Using phenotypic test systems and genotypic analysis, it has been shown that the mutant strain J96-M1 has lost the hlyII, prs and cnf1 genes. The three virulence associated determinants are linked on one particular region on the chromosome, which is termed 'pathogenicity island II' (Pai II).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adhesins, Bacterial / genetics*
  • Bacterial Toxins / genetics*
  • Chromosome Mapping
  • Cytotoxins / genetics*
  • Escherichia coli / genetics*
  • Escherichia coli Proteins*
  • Hemolysin Proteins / genetics*
  • Multigene Family
  • Mutation

Substances

  • Adhesins, Bacterial
  • Bacterial Toxins
  • Cytotoxins
  • Escherichia coli Proteins
  • Hemolysin Proteins
  • cytotoxic necrotizing factor type 1