Differential localization of mRNAs encoding dopamine D1 or D2 receptors in cholinergic neurons in the core and shell of the rat nucleus accumbens

Brain Res Mol Brain Res. 1995 Jan;28(1):169-74. doi: 10.1016/0169-328x(94)00239-b.


By combining immunocytochemistry for ChAT and in situ hybridization for dopamine D1 or D2 receptor mRNA in the striatum, it was found that (1) the percentage of ChAT/D2 mRNA co-localization is higher in the caudate-putamen than in the shell and core of the nucleus accumbens, (2) in the shell the degree of ChAT/D2 mRNA co-localization is higher rostrally than caudally, and 3) no significant regional differences exist in the degree of co-localization of ChAT and D1 mRNA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Basal Ganglia / metabolism*
  • Caudate Nucleus / metabolism
  • Corpus Striatum / metabolism*
  • Immunohistochemistry
  • In Situ Hybridization
  • Nucleus Accumbens / chemistry*
  • Nucleus Accumbens / metabolism
  • RNA, Messenger / analysis
  • RNA, Messenger / genetics*
  • Rats
  • Receptors, Dopamine D1 / biosynthesis
  • Receptors, Dopamine D1 / metabolism*
  • Receptors, Dopamine D2 / biosynthesis
  • Receptors, Dopamine D2 / metabolism*


  • RNA, Messenger
  • Receptors, Dopamine D1
  • Receptors, Dopamine D2