Real-time functional magnetic resonance imaging

Magn Reson Med. 1995 Feb;33(2):230-6. doi: 10.1002/mrm.1910330213.


A recursive algorithm suitable for functional magnetic resonance imaging (FMRI) calculations is presented. The correlation coefficient of a time course of images with a reference time series, with the mean and any linear trend projected out, may be computed with 22 operations per voxel, per image; the storage overhead is four numbers per voxel. A statistical model for the FMRI signal is presented, and thresholds for the correlation coefficient are derived from it. Selected images from the first real-time functional neuroimaging experiment (at 3 Tesla) are presented. Using a 50-MHz workstation equipped with a 14-bit analog-to-digital converter, each echo planar image was acquired, reconstructed, correlated, thresholded, and displayed in pseudocolor (highlighting active regions in the brain) within 500 ms of the RF pulse.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Algorithms
  • Analog-Digital Conversion
  • Brain / anatomy & histology
  • Brain / physiology
  • Color
  • Computer Systems
  • Data Display
  • Echo-Planar Imaging / methods
  • Echo-Planar Imaging / statistics & numerical data
  • Fingers / physiology
  • Humans
  • Image Processing, Computer-Assisted / methods*
  • Image Processing, Computer-Assisted / statistics & numerical data
  • Likelihood Functions
  • Magnetic Resonance Imaging / methods*
  • Magnetic Resonance Imaging / statistics & numerical data
  • Models, Statistical
  • Motor Skills / physiology
  • Time Factors