Barbiturate-reversible reduction of water diffusion coefficient in flurothyl-induced status epilepticus in rats

Magn Reson Med. 1995 Feb;33(2):253-6. doi: 10.1002/mrm.1910330216.


Rat brains (n = 17) with flurothyl-induced status epilepticus (SE) have been imaged with a gradient-echo diffusion-weighted imaging sequence at 2.0 T. The apparent water diffusion coefficient (ADC) decreased during seizure discharges. The magnitude of the ADC reduction correlated well with the duration of flurothyl exposure. A 17% reduction in the water ADC compared with preseizure condition was observed in rats with the longest flurothyl exposure time. In 13 rats, pentobarbital was used to arrest the electrographic seizure activity. ADC values began to return to normal a few minutes after the injection. In four rats with no pentobarbital administration, ADC values remained depressed up to 1 h after seizure onset. The results suggest that diffusion-weighted MR imaging may be useful for mapping recent intense seizure activity in human patients with medically intractable epilepsy.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Bicuculline / adverse effects
  • Body Water / drug effects*
  • Body Water / metabolism*
  • Brain / drug effects*
  • Brain / metabolism*
  • Diffusion
  • Dose-Response Relationship, Drug
  • Electroencephalography / drug effects
  • Female
  • Flurothyl / administration & dosage
  • Flurothyl / adverse effects*
  • Halothane / pharmacology
  • Magnetic Resonance Imaging*
  • Morphine / pharmacology
  • Nitrous Oxide / pharmacology
  • Pentobarbital / pharmacology*
  • Pentobarbital / therapeutic use
  • Rats
  • Status Epilepticus / chemically induced*
  • Status Epilepticus / drug therapy
  • Status Epilepticus / metabolism*
  • Time Factors


  • Morphine
  • Flurothyl
  • Pentobarbital
  • Nitrous Oxide
  • Halothane
  • Bicuculline