Genetic and pathogenic basis of autoimmune diabetes in NOD mice

Curr Opin Immunol. 1994 Dec;6(6):900-6. doi: 10.1016/0952-7915(94)90011-6.


Non-obese diabetic (NOD) mice are an excellent model of T-cell mediated autoimmune insulin-dependent diabetes in humans. Recent studies in NOD mice have shown that this disease is a result of epistatic interactions between multiple genes, both inside and outside the major histocompatibility complex (MHC), generating T cells reactive against an expanding repertoire of autoantigens.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Autoantigens / immunology
  • Autoimmunity / immunology*
  • Diabetes Mellitus, Type 1 / genetics*
  • Diabetes Mellitus, Type 1 / immunology*
  • Haplotypes
  • Humans
  • Islets of Langerhans / immunology
  • Major Histocompatibility Complex / genetics
  • Major Histocompatibility Complex / immunology
  • Mice
  • Mice, Inbred NOD
  • T-Lymphocytes / immunology


  • Autoantigens