Autoimmunity in the Eye and Its Regulation

Curr Opin Immunol. 1994 Dec;6(6):938-45. doi: 10.1016/0952-7915(94)90017-5.

Abstract

Recent studies have provided new information concerning the development of autoimmune-mediated intraocular inflammation (uveitis) and the mechanisms that suppress this sight-robbing process. Newly collected data have led to several interesting advances: the discovery of additional uveitogenic antigens and novel uveitogenic reactions; dissection of the early steps of the pathogenic process; identification of the subsets of lymphocytes that selectively accumulate in the inflamed eye; analysis of the development of tolerance against sequestered antigens in the eye; elucidation of the cellular and molecular events of the anterior chamber-associated immune deviation, the major immunoregulatory mechanism in the eye; the capacity of this mechanism to inhibit and even treat uveitis; and examination of the mechanisms whereby oral tolerance inhibits ocular inflammation.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Anterior Chamber / immunology
  • Autoantigens / immunology
  • Autoimmune Diseases / immunology
  • Autoimmunity / immunology*
  • Eye / immunology*
  • Eye Proteins / chemistry
  • Eye Proteins / immunology
  • Humans
  • Molecular Sequence Data
  • Receptors, Antigen, T-Cell / immunology
  • Uveitis / immunology*
  • Uveitis / prevention & control

Substances

  • Autoantigens
  • Eye Proteins
  • Receptors, Antigen, T-Cell