Annexin VI has tumour-suppressor activity in human A431 squamous epithelial carcinoma cells

Br J Cancer. 1995 Apr;71(4):786-8. doi: 10.1038/bjc.1995.152.


In this study we show that heterologous expression of annexin VI in A431 squamous carcinoma cells caused a marked suppression of tumour cell growth when cells were cultured subcutaneously in nude mice. The tumours formed by the annexin VI+ A431 cells were morphologically and histologically similar to those formed by the wild-type cells.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Annexin A6 / analysis
  • Annexin A6 / biosynthesis*
  • Carcinoma, Squamous Cell / metabolism
  • Carcinoma, Squamous Cell / pathology*
  • Cell Line
  • Clone Cells
  • Humans
  • Immunohistochemistry
  • Mice
  • Mice, Nude
  • Transplantation, Heterologous
  • Tumor Cells, Cultured


  • Annexin A6