The putative Drosophila NMDARA1 gene is located on the second chromosome and is ubiquitously expressed in embryogenesis

Biochim Biophys Acta. 1995 Apr 4;1261(2):301-3. doi: 10.1016/0167-4781(95)00031-b.


We describe the cDNA sequence of a Drosophila gene located at 49D on the second chromosome. The predicted protein sequence has extensive homology (46% identity, 76% similarity) along its entire length to the central portion of the mammalian brain-specific NMDARA1 glutamate binding protein. While RNA expression studies of the Drosophila protein shown that it is ubiquitously expressed throughout embryogenesis, there appears to be a selective accumulation of transcript in the precursor for the larval brain. The similarity in both expression and sequence suggests that the two proteins may share a conserved function.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • DNA, Complementary / chemistry
  • Drosophila / embryology
  • Drosophila / genetics*
  • Larva
  • Molecular Sequence Data
  • Nerve Tissue Proteins / chemistry
  • Nerve Tissue Proteins / genetics*
  • Receptors, N-Methyl-D-Aspartate / chemistry*
  • Sequence Alignment


  • DNA, Complementary
  • NMDA receptor A1
  • Nerve Tissue Proteins
  • Receptors, N-Methyl-D-Aspartate

Associated data

  • GENBANK/L37377