The complete nucleotide sequence of the mouse thyroid-specific enhancer-binding protein (T/EBP) gene: extensive identity of the deduced amino acid sequence with the human protein

H Oguchi; Y T Pan; S Kimura

doi:10.1016/0167-4781(95)00033-d

The complete nucleotide sequence of the mouse thyroid-specific enhancer-binding protein (T/EBP) gene: extensive identity of the deduced amino acid sequence with the human protein

Biochim Biophys Acta. 1995 Apr 4;1261(2):304-6. doi: 10.1016/0167-4781(95)00033-d.

Authors

H Oguchi¹, Y T Pan, S Kimura

Affiliation

¹ Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, MD 20892, USA.

PMID: 7711079
DOI: 10.1016/0167-4781(95)00033-d

Abstract

A mouse thyroid-specific enhancer-binding protein (T/EBP) gene and its flanking regions have been cloned and completely sequenced. The gene consists of 2 exons and exhibits high similarity (83-97%) to the rat sequence throughout the coding region and including an intron and up to 1.3 kbp upstream to the ATG initiation codon. A cDNA clone encoding human T/EBP has been also isolated and sequenced. Comparison of the deduced amino acid sequence of T/EBP revealed an extensive identity of 98% between mouse and the human protein.

Publication types

Comparative Study

MeSH terms

Amino Acid Sequence
Animals
Base Sequence
Cloning, Molecular
Codon
Humans
Introns
Mice
Molecular Sequence Data
Nuclear Proteins / genetics*
Sequence Alignment
Thyroid Nuclear Factor 1
Transcription Factors / genetics*

Substances

Codon
Nuclear Proteins
Thyroid Nuclear Factor 1
Transcription Factors

Associated data

GENBANK/U19755
GENBANK/U19756