Cloning and sequence analysis of human thyroid transcription factor 1

A Saiardi; V Tassi; V De Filippis; D Civitareale

doi:10.1016/0167-4781(95)00034-e

Cloning and sequence analysis of human thyroid transcription factor 1

Biochim Biophys Acta. 1995 Apr 4;1261(2):307-10. doi: 10.1016/0167-4781(95)00034-e.

Authors

A Saiardi¹, V Tassi, V De Filippis, D Civitareale

Affiliation

¹ Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, Laboratory of Cellular and Molecular Endocrinology, Santa Maria Imbaro, Italy.

PMID: 7711080
DOI: 10.1016/0167-4781(95)00034-e

Abstract

The thyroid transcription factor 1 (TTF-1) is a homeodomain-containing transcription factor that activates the transcriptional activity of thyroid-specific gene promoters by binding to them. Hence, TTF-1 is crucial in the maintenance of the thyroid differentiation phenotype. The authors isolated and analysed the human TTF-1 gene, which shows a striking homology with the rat TTF-1 gene.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Base Sequence
Cell Differentiation / genetics
Cloning, Molecular
Gene Expression Regulation
Humans
Iodide Peroxidase / genetics
Molecular Sequence Data
Nuclear Proteins / biosynthesis
Nuclear Proteins / genetics*
Receptors, Thyrotropin / genetics
Sequence Homology, Nucleic Acid
Thyroglobulin / genetics
Thyroid Nuclear Factor 1
Transcription Factors / biosynthesis
Transcription Factors / genetics*

Substances

NKX2-1 protein, human
Nuclear Proteins
Receptors, Thyrotropin
Thyroid Nuclear Factor 1
Transcription Factors
Thyroglobulin
Iodide Peroxidase

Associated data

GENBANK/X82850