Rolipram, a cyclic AMP-selective phosphodiesterase inhibitor, reduces neuronal damage following cerebral ischemia in the gerbil

Eur J Pharmacol. 1995 Jan 5;272(1):107-10. doi: 10.1016/0014-2999(94)00694-3.

Abstract

We examined the effects of rolipram, a cyclic AMP-selective phosphodiesterase inhibitor, on cerebral ischemia-induced neuronal damage in Mongolian gerbils. Transient forebrain ischemia was induced by 3-min occlusion of bilateral common carotid arteries. Rolipram, at a dose of 0.3 or 3 mg/kg, was injected i.p. 30 min before ischemia. Histopathological observations showed that neuronal damage to the hippocampal CA1 subfield, which was seen 7 days after ischemia in vehicle-treated animals, was reduced in animals treated with the higher dose of rolipram.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Gerbillinae
  • Hippocampus / cytology
  • Hippocampus / drug effects*
  • Hippocampus / pathology
  • Injections, Intraperitoneal
  • Ischemic Attack, Transient / drug therapy
  • Ischemic Attack, Transient / pathology*
  • Male
  • Neurons / drug effects*
  • Neurons / pathology
  • Phosphodiesterase Inhibitors / administration & dosage
  • Phosphodiesterase Inhibitors / pharmacology*
  • Phosphodiesterase Inhibitors / therapeutic use
  • Prosencephalon / cytology
  • Prosencephalon / drug effects*
  • Prosencephalon / pathology
  • Pyrrolidinones / administration & dosage
  • Pyrrolidinones / pharmacology*
  • Pyrrolidinones / therapeutic use
  • Rolipram

Substances

  • Phosphodiesterase Inhibitors
  • Pyrrolidinones
  • Rolipram