The role of prolactin in the menopause

Maturitas. 1994 Dec;20(2-3):151-4. doi: 10.1016/0378-5122(94)90011-6.

Abstract

Within a study on menopausal discomforts, 2322 women were seen for the first time at the Outpatients Department for Climacteric Disturbances and Prophylaxis of Osteoporosis at our clinic. Amongst routine hormonal examination we measured prolactin levels. We found hyperprolactinemia in 23 women. Furthermore, in 224 women who initially had normal hPRL values, an estrogen-gestagen replacement therapy was administered and within this we found a significant increase of the prolactin levels (P < 0.005). The role of prolactin in the climacteric period as well as the mechanism of the estrogen effect upon prolactin secretion are subjects of discussion.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Climacteric / drug effects
  • Climacteric / physiology*
  • Drug Therapy, Combination
  • Estradiol / blood
  • Estrogen Replacement Therapy
  • Estrogens, Conjugated (USP) / administration & dosage
  • Female
  • Follicle Stimulating Hormone / blood
  • Humans
  • Hyperprolactinemia / blood
  • Luteinizing Hormone / blood
  • Medrogestone / administration & dosage
  • Menopause / drug effects
  • Menopause / physiology*
  • Middle Aged
  • Pituitary Function Tests
  • Prolactin / blood*

Substances

  • Estrogens, Conjugated (USP)
  • Medrogestone
  • Estradiol
  • Prolactin
  • Luteinizing Hormone
  • Follicle Stimulating Hormone