Late motor involvement in cases presenting as "chronic sensory demyelinating polyneuropathy"

Muscle Nerve. 1995 Apr;18(4):440-4. doi: 10.1002/mus.880180411.


Chronic inflammatory demyelinating polyneuropathy (CIDP) is usually characterized by prominent motor deficits. A pure sensory presentation, labeled chronic sensory demyelinating neuropathy (CSDN), has been reported, but it is unclear if this neuropathy is a distinct clinical and immunologic entity or merely the sensory presentation of the more usual sensorimotor CIDP. We describe 5 patients with what initially appeared to be CSDN; 3 subsequently developed substantial weakness coincident with the electrophysiologic appearance of multifocal motor conduction block. These cases indicate that, in some cases, CSDN may be a transitional clinical stage of CIDP in which the more usual sensorimotor deficits develop later. Immune-based therapy, including intravenous immunoglobulin, was found to be effective in both the pure sensory and sensorimotor types.

Publication types

  • Case Reports

MeSH terms

  • Chronic Disease
  • Demyelinating Diseases / physiopathology*
  • Demyelinating Diseases / therapy
  • Female
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use
  • Middle Aged
  • Muscles / physiopathology*
  • Neural Conduction
  • Neuritis / physiopathology
  • Neuritis / therapy
  • Peripheral Nervous System Diseases / physiopathology*
  • Peripheral Nervous System Diseases / therapy
  • Sensation Disorders / physiopathology*
  • Sensation Disorders / therapy


  • Immunoglobulins, Intravenous