Degradation of hyaluronate by the concerted action of ozone and sunlight

Ophthalmic Res. 1994;26(6):340-3. doi: 10.1159/000267499.


The influence of ozone and sunlight in a concerted reaction on hyaluronate solutions was investigated. The kinematic viscosity of hyaluronate solutions is decreased by ozone-air mixtures and simultaneous radiation with sun rays within a few minutes, indicating a depolymerization of the hyaluronate molecule. The reaction is dependent on the concentration of ozone and on the time of exposure to ozone and sunlight. The concerted degradation of hyaluronate is more effective than the reaction with each component, ozone and sun rays, alone. We conclude that hyaluronate depolymerization by ozone and sunlight may be one factor for irritations of the eye by photochemical smog and increased exposure to sun rays.

MeSH terms

  • Animals
  • Cattle
  • Dose-Response Relationship, Drug
  • Drug Combinations
  • Hyaluronic Acid / radiation effects*
  • In Vitro Techniques
  • Ozone / adverse effects*
  • Polymers / radiation effects
  • Sunlight
  • Time Factors
  • Ultraviolet Rays / adverse effects*
  • Viscosity / drug effects*
  • Viscosity / radiation effects*


  • Drug Combinations
  • Polymers
  • Ozone
  • Hyaluronic Acid