Rectal blood flow in ulcerative colitis

Am J Gastroenterol. 1995 Apr;90(4):579-80.


Objective: To determine the state of local blood flow in ulcerative colitis.

Methods: Rectal blood flow was measured by means of laser Doppler flowmetry during endoscopy in 20 patients with active or inactive ulcerative colitis and in 20 healthy controls.

Results: A significant (p < 0.01) reduction in the values of rectal perfusion was observed in ulcerative colitis patients both in active phase and in clinical and endoscopic remission.

Conclusions: Impaired local blood flow may have a pathogenetic role in ulcerative colitis. Remission of the disease is not accompanied by normalization of local microcirculation, which may predispose to relapses.

MeSH terms

  • Adult
  • Colitis, Ulcerative / physiopathology*
  • Colonoscopy
  • Female
  • Humans
  • Laser-Doppler Flowmetry
  • Male
  • Microcirculation
  • Middle Aged
  • Rectum / blood supply*
  • Regional Blood Flow