HLA-DR8 and acute anterior uveitis in ankylosing spondylitis

Arthritis Rheum. 1995 Apr;38(4):547-50. doi: 10.1002/art.1780380414.


Objective: To identify possible factors in the development of acute anterior uveitis (AUU) in patients with ankylosing spondylitis (AS).

Methods: We investigated HLA antigens serologically, and HLA-DRB1*08 alleles by polymerase chain reaction-restriction fragment length polymorphism, in 42 Japanese AS patients with and without AAU.

Results: Thirty-six of the AS patients (85.7%) had HLA-B27. Thirteen (65%) of the 20 patients with AAU had HLA-DR8, whereas only 1 (4.5%) of the 22 patients without AAU had DR8. The difference was statistically significant (Pcorr < 0.001).

Conclusion: Our data suggest that HLA-B27 is strongly associated with AS in Japanese patients and that HLA-DR8 is important for the development of AAU in Japanese patients with AS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Adult
  • Asians
  • Base Sequence
  • Female
  • HLA Antigens / analysis
  • HLA Antigens / classification
  • HLA-B27 Antigen / analysis
  • HLA-DR Antigens / analysis*
  • HLA-DR Serological Subtypes
  • Humans
  • Male
  • Molecular Probes / genetics
  • Molecular Sequence Data
  • Reference Values
  • Spondylitis, Ankylosing / complications
  • Spondylitis, Ankylosing / immunology*
  • Uveitis, Anterior / complications
  • Uveitis, Anterior / immunology*


  • HLA Antigens
  • HLA-B27 Antigen
  • HLA-DR Antigens
  • HLA-DR Serological Subtypes
  • HLA-DR8 antigen
  • Molecular Probes