The Regulation and Function of p21ras During T-cell Activation and Growth

Immunol Today. 1995 Mar;16(3):159-64. doi: 10.1016/0167-5699(95)80134-0.


The delivery of signals that control the growth of T cells is a key event for effective co-ordination of T-cell-dependent immune responses. It is now recognized that guanine nucleotide binding proteins play an important role in signal transduction by the T-cell receptor (TCR) and cytokine receptors. Here, Manolo Izquierdo Pastor, Karin Reif and Doreen Cantrell review the numerous recent advances in understanding how the p21ras guanine nucleotide binding protein couples the TCR to the T-cell signalling cascade.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Lymphocyte Activation / immunology*
  • Proto-Oncogene Proteins p21(ras) / physiology*
  • Receptors, Antigen, T-Cell / physiology
  • Receptors, Cytokine / physiology
  • Signal Transduction / physiology
  • T-Lymphocytes / immunology*


  • Receptors, Antigen, T-Cell
  • Receptors, Cytokine
  • HRAS protein, human
  • Proto-Oncogene Proteins p21(ras)