Delayed hypersensitivity to one low-molecular-weight heparin with tolerance of other low-molecular-weight heparins

Br J Dermatol. 1995 Mar;132(3):461-3. doi: 10.1111/j.1365-2133.1995.tb08684.x.


We report a patient who developed infiltrated plaques at the sites of subcutaneous injection of a low-molecular-weight heparin. Skin tests and a lymphocyte transformation test revealed hypersensitivity to sandoparin and heparin sodium. The low-molecular-weight heparins nadroparin and dalteparin were subsequently tolerated without adverse effects. Possible risk factors for sensitization are discussed.

Publication types

  • Case Reports

MeSH terms

  • Drug Hypersensitivity
  • Drug Tolerance
  • Female
  • Heparin, Low-Molecular-Weight / adverse effects*
  • Heparin, Low-Molecular-Weight / immunology
  • Humans
  • Hypersensitivity, Delayed / chemically induced*
  • Lymphocyte Activation
  • Middle Aged
  • Skin Tests
  • Varicose Ulcer / drug therapy


  • Heparin, Low-Molecular-Weight