Why does the human visual system age in the way it does?

Exp Eye Res. 1995 Jan;60(1):49-55. doi: 10.1016/s0014-4835(05)80083-1.


The tentative observation that the decrease of lenticular glutathione in man and in cattle may be under genetic control is extended to other biological functions which show a systematic reduction with age. Ocular and visual parameters are shown to decline consistently with the view that the human eye has evolved in keeping with other biological functions sustaining a life-span of approximately 120 years. Analysis of the data suggests that presbyopia represents an outlier in the distribution of ocular attributes, and should not be used as a biomarker for ageing.

Publication types

  • Meta-Analysis

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aging / physiology*
  • Animals
  • Glutathione / metabolism
  • Humans
  • Lens, Crystalline / metabolism
  • Longevity
  • Ocular Physiological Phenomena
  • Presbyopia / etiology*
  • Vision, Ocular / physiology


  • Glutathione