Screening and sequence determination of a cDNA encoding the human brain 4-aminobutyrate aminotransferase

Gene. 1995 Apr 3;155(2):185-7. doi: 10.1016/0378-1119(94)00858-p.

Abstract

A human brain cDNA library constructed in the lambda ZAP II vector was screened using a fragment of pig brain cDNA encoding 4-aminobutyrate aminotransferase (pGaba-t). A cDNA that encodes the human brain Gaba-t (hGaba-t) has been isolated from the library and sequenced. Using the GenBank and EMBL databases, comparison of the predicted amino-acid sequence of hGaba-t with the pig enzyme revealed 95.4% homology.

Publication types

  • Comparative Study

MeSH terms

  • 4-Aminobutyrate Transaminase / genetics*
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Brain / enzymology*
  • DNA, Complementary / genetics*
  • Humans
  • Molecular Sequence Data
  • Sequence Alignment
  • Sequence Analysis
  • Swine

Substances

  • DNA, Complementary
  • 4-Aminobutyrate Transaminase

Associated data

  • GENBANK/L32961
  • GENBANK/M84802