Structure, sequence and location of the UQCRFS1 gene for the human Rieske Fe-S protein

Gene. 1995 Apr 3;155(2):207-11. doi: 10.1016/0378-1119(94)00683-j.


We have identified and studied the chromosomal location of the human Rieske Fe-S protein-encoding gene UQCRFS1. Mapping by hybridization to a panel of monochromosomal hybrid cell lines indicated that a UQCRFS1 partial cDNA was derived from either chromosome 19 or 22. By screening a human chromosome 19 specific genomic cosmid library with a probe from this cDNA sequence, we identified a corresponding cosmid. Portions of this cosmid were sequenced directly. The exon, exon:intron junction and flanking sequences verified that this cosmid contains the genomic locus. Fluorescent in situ hybridization (FISH) was performed to localize this cosmid to chromosome band 19q12.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Cell Line
  • Chromosome Mapping*
  • Chromosomes, Human, Pair 19 / genetics*
  • Chromosomes, Human, Pair 22 / genetics*
  • DNA, Complementary / genetics
  • Electron Transport Complex III*
  • Genome
  • Humans
  • Iron-Sulfur Proteins / genetics*
  • Molecular Sequence Data


  • DNA, Complementary
  • Iron-Sulfur Proteins
  • Rieske iron-sulfur protein
  • Electron Transport Complex III

Associated data

  • GENBANK/L32917
  • GENBANK/L32977