Complementary DNA characterization and chromosomal localization of a human gene related to the poliovirus receptor-encoding gene

Gene. 1995 Apr 3;155(2):261-5. doi: 10.1016/0378-1119(94)00842-g.


The human poliovirus (PV) receptor (PVR) is a member of the immunoglobulin (Ig) superfamily with unknown cellular function. We have isolated a human PVR-related (PRR) cDNA. The deduced amino acid (aa) sequence of PRR showed, in the extracellular region, 51.7 and 54.3% similarity with human PVR and with the murine PVR homolog, respectively. The cDNA coding sequence is 1.6-kb long and encodes a deduced 57-kDa protein; this protein has a structural organization analogous to that of PVR, that is, one V- and two C-set Ig domains, with a conserved number of aa. Northern blot analysis indicated that a major 5.9-kb transcript is present in all normal human tissues tested. In situ hybridization showed that the PRR gene is located at bands q23-q24 of human chromosome 11.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Carcinoma / metabolism
  • Chromosome Mapping
  • Chromosomes, Human, Pair 11 / genetics*
  • Cloning, Molecular
  • DNA, Complementary / genetics
  • Humans
  • Membrane Proteins*
  • Mice
  • Molecular Sequence Data
  • Receptors, Virus / genetics*
  • Sequence Alignment
  • Tumor Cells, Cultured
  • Urinary Bladder Neoplasms / metabolism


  • DNA, Complementary
  • Membrane Proteins
  • Receptors, Virus
  • poliovirus receptor

Associated data

  • GENBANK/X76400