Point Mutations in the Dihydrofolate Reductase-Thymidylate Synthase Gene and Pyrimethamine and Cycloguanil Resistance in Plasmodium Falciparum

Mol Biochem Parasitol. 1995 Jan;69(1):135-8. doi: 10.1016/0166-6851(94)00207-4.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Drug Resistance, Multiple
  • Humans
  • Malaria, Falciparum / parasitology
  • Plasmodium falciparum / drug effects*
  • Plasmodium falciparum / genetics*
  • Point Mutation
  • Proguanil
  • Pyrimethamine / pharmacology*
  • Tetrahydrofolate Dehydrogenase / genetics*
  • Thymidylate Synthase / genetics*
  • Triazines / pharmacology*

Substances

  • Triazines
  • cycloguanil
  • Tetrahydrofolate Dehydrogenase
  • Thymidylate Synthase
  • Proguanil
  • Pyrimethamine