The effect of forskolin on blood flow, platelet metabolism, aggregation and ATP release

Vasa. 1995;24(1):56-61.


Forskolin, a diterpene obtained from coleus forskolii, is a potent cAMP stimulator. We have evaluated the effects of forskolin on blood flow, platelet aggregation and metabolism. It was found that forskolin has a dose dependent vaso-relaxing effect in an in vivo sheep model, when infused intra-arterially. Furthermore forskolin, in a dose-dependent fashion reduced whole blood platelet aggregation and ATP release. Pretreatment of PTFE grafts with Forskolin significantly reduced platelet consumption 3 hours postoperatively and on the first postoperative day. The overall platelet metabolism, measured by a microcalorimetric technique after treatment with forskolin in vitro and ex-vivo postoperatively was significantly increased.

In conclusion: Forskolin affects blood flow and platelet parameters favourably in the setting of occlusive arterial disease and reconstructive arterial surgery.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphate / blood*
  • Animals
  • Blood Flow Velocity / drug effects
  • Blood Flow Velocity / physiology
  • Blood Platelets / drug effects*
  • Blood Platelets / metabolism
  • Blood Vessel Prosthesis
  • Colforsin / pharmacology*
  • Dose-Response Relationship, Drug
  • Graft Occlusion, Vascular / blood
  • Hindlimb / blood supply*
  • Male
  • Platelet Aggregation / drug effects*
  • Platelet Aggregation / physiology
  • Platelet Aggregation Inhibitors / pharmacology*
  • Polytetrafluoroethylene
  • Sheep


  • Platelet Aggregation Inhibitors
  • Colforsin
  • Adenosine Triphosphate
  • Polytetrafluoroethylene