Multipoint interval mapping of quantitative trait loci, using sib pairs

Am J Hum Genet. 1995 May;56(5):1224-33.


The sib-pair interval-mapping procedure of Fulker and Cardon is extended to take account of all available marker information on a chromosome simultaneously. The method provides a computationally fast multipoint analysis of sib-pair data, using a modified Haseman-Elston approach. It gives results very similar to those of the earlier interval-mapping procedure when marker information is relatively uniform and a coarse map is used. However, there is a substantial improvement over the original method when markers differ in information content and/or when a dense map is employed. The method is illustrated by using simulated sib-pair data.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • Chromosome Mapping / methods*
  • Computer Simulation*
  • Genetic Markers
  • Humans
  • Models, Genetic*
  • Nuclear Family*
  • Statistics as Topic / methods
  • Time Factors


  • Genetic Markers