Host-range Control of a Retroviral Disease: Friend Erythroleukemia

Trends Microbiol. 1995 Feb;3(2):51-7. doi: 10.1016/s0966-842x(00)88875-7.

Abstract

Since its discovery in 1957, Friend viral erythroleukemia has been the major model for understanding host genetic barriers to retroviral diseases and has facilitated the discovery of many polymorphic leukemia-control genes of mice. Some of these genes limit helper-virus replication, target-cell (erythroblast) pools or immune responses. At least one host gene appears to block the viral oncoprotein.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Friend murine leukemia virus / genetics
  • Friend murine leukemia virus / pathogenicity*
  • Humans
  • Leukemia, Experimental / virology
  • Mice
  • Molecular Sequence Data
  • Retroviridae Infections / virology
  • Spleen Focus-Forming Viruses / genetics
  • Spleen Focus-Forming Viruses / pathogenicity*
  • Viral Envelope Proteins / genetics
  • Viral Envelope Proteins / physiology*

Substances

  • Viral Envelope Proteins
  • glycoprotein gp55, Friend spleen focus-forming virus