Host-range Control of a Retroviral Disease: Friend Erythroleukemia

Trends Microbiol. 1995 Feb;3(2):51-7. doi: 10.1016/s0966-842x(00)88875-7.


Since its discovery in 1957, Friend viral erythroleukemia has been the major model for understanding host genetic barriers to retroviral diseases and has facilitated the discovery of many polymorphic leukemia-control genes of mice. Some of these genes limit helper-virus replication, target-cell (erythroblast) pools or immune responses. At least one host gene appears to block the viral oncoprotein.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Friend murine leukemia virus / genetics
  • Friend murine leukemia virus / pathogenicity*
  • Humans
  • Leukemia, Experimental / virology
  • Mice
  • Molecular Sequence Data
  • Retroviridae Infections / virology
  • Spleen Focus-Forming Viruses / genetics
  • Spleen Focus-Forming Viruses / pathogenicity*
  • Viral Envelope Proteins / genetics
  • Viral Envelope Proteins / physiology*


  • Viral Envelope Proteins
  • glycoprotein gp55, Friend spleen focus-forming virus