Tissue-culture invasion: fact or artefact?

Trends Microbiol. 1995 Feb;3(2):69-71. doi: 10.1016/s0966-842x(00)88878-2.


Although widely used, tissue-culture assays cannot be exact models of the conditions that are met in vivo by pathogenic bacteria. However, recent studies of specific mutants suggest that the model is good for highly invasive bacteria, but it remains to be seen if this is true for weakly invasive bacteria.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Bacteria / pathogenicity*
  • Bacterial Adhesion*
  • Bacterial Physiological Phenomena
  • Cells, Cultured / microbiology*
  • Cytological Techniques
  • Humans