Up-regulation of the oligosaccharide sialyl LewisX: a new prognostic parameter in metastatic prostate cancer

Cancer Res. 1995 May 1;55(9):1817-9.


Metastatic prostate cancer has an unpredictable long-term prognosis. At present, there are few specific predictors to indicate the outcome for the individual patient. We have studied immunoreactivity for type-2 carbohydrate structures, known to be involved in various cell adhesion processes, in patients with metastatic prostate cancer. One group of patients (n = 26) did not progress within 3 years after orchiectomy, while another group of patients (n = 33) progressed within 1 year following castration and survived less than 2 years. Among the parameters studied, sialyl LewisX carbohydrate up-regulation was the only variable showing significant association with poor prognosis (P < 0.01). Sialyl LewisX discriminated between these two outcome groups with 71% predictability and 96% specificity. Our results indicate that up-regulation of sialyl LewisX is associated with hormonal-resistant, aggressive disease. This prognostic marker may, therefore, have an important role in selecting proper treatment for patients with metastatic prostate cancer.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / chemistry*
  • Adenocarcinoma / pathology
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor / analysis*
  • Carbohydrate Sequence
  • Humans
  • Immunohistochemistry
  • Lewis X Antigen / analysis
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Neoplasm Metastasis
  • Oligosaccharides / analysis*
  • Oligosaccharides / metabolism
  • Predictive Value of Tests
  • Prognosis
  • Prostatic Neoplasms / chemistry*
  • Prostatic Neoplasms / pathology
  • Sialyl Lewis X Antigen
  • Up-Regulation / physiology*


  • Biomarkers, Tumor
  • Lewis X Antigen
  • Oligosaccharides
  • Sialyl Lewis X Antigen