Reduction of oxidative DNA-damage in humans by brussels sprouts

Carcinogenesis. 1995 Apr;16(4):969-70. doi: 10.1093/carcin/16.4.969.


The effect of consumption of Brussels sprouts on levels of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) in human urine was investigated in 10 healthy, male, non-smoking volunteers. Following a 3 week run-in period, five volunteers continued on a diet free of cruciferous vegetables for a subsequent 3 week intervention period (control group), while the other five (sprouts group) consumed 300 g of cooked Brussels sprouts per day, at the expense of 300 g of a glucosinolate-free vegetable. Levels of 8-oxodG in 24 h urine samples were measured by HPLC. In the control group there was no difference between the two periods in levels of 8-oxodG (P = 0.72). In contrast, in the sprouts group the levels of 8-oxodG were decreased by 28% during the intervention period (P = 0.039). The present findings support the results of epidemiologic studies that consumption of cruciferous vegetables may result in a decreased cancer risk.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • 8-Hydroxy-2'-Deoxyguanosine
  • Anticarcinogenic Agents / therapeutic use*
  • Antimutagenic Agents / therapeutic use*
  • Antioxidants / therapeutic use*
  • Brassica*
  • DNA / drug effects
  • DNA / metabolism
  • DNA Damage*
  • Deoxyguanosine / analogs & derivatives
  • Deoxyguanosine / metabolism
  • Deoxyguanosine / urine
  • Diet
  • Humans
  • Male
  • Oxidation-Reduction
  • Vegetables*


  • Anticarcinogenic Agents
  • Antimutagenic Agents
  • Antioxidants
  • 8-Hydroxy-2'-Deoxyguanosine
  • DNA
  • Deoxyguanosine