The synthesis of N-hydroxy-N'-phenyloctanediamide and its inhibitory effect on proliferation of AXC rat prostate cancer cells

J Med Chem. 1995 Apr 14;38(8):1411-3. doi: 10.1021/jm00008a020.


We have developed a practical synthesis of N-hydroxy-N'-phenyloctanediamide from the methyl ester of suberanilic acid. It provides the product in high yield and purity with a simple purification process. We have found that at 10(-5) M it has a dramatic effect on T/5 AXC/SSh rat prostate cancer cells in vitro. It is a potent inhibitor of cell proliferation and it changes the cell morphology to resemble nonmalignant cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amides / chemical synthesis*
  • Amides / pharmacology
  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology
  • Cell Division / drug effects
  • Drug Screening Assays, Antitumor
  • Hydroxamic Acids
  • Male
  • Prostatic Neoplasms / drug therapy*
  • Rats
  • Tumor Cells, Cultured
  • Vorinostat


  • Amides
  • Antineoplastic Agents
  • Hydroxamic Acids
  • Vorinostat