[Scleroderma and occupational factors: a case-control study and analysis of literature]

Med Lav. Nov-Dec 1994;85(6):496-506.
[Article in Italian]


The scientific literature concerning occupational factors associated with scleroderma consists mostly of case report type studies. We therefore undertook a case-control study in the Province of Trento using as data source the Hospital Records System. The annual rate of scleroderma incidence in the period considered (1976-1991) was 5.8 per million in females and 1.5 per million in males. A statistically significant association was observed (OR = 9.28, p = 0.039) in the population under study for occupational exposure to solvents. Also, an excess risk was observed in male subjects exposed to silica dust, even though the simultaneous exposure to other risk factors, such as hand-arm vibrations, makes it difficult to establish the specific contribution of silica dust exposure.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Air Pollutants, Occupational / adverse effects*
  • Epoxy Resins / adverse effects
  • Female
  • Humans
  • Hydrocarbons, Chlorinated / adverse effects
  • Male
  • Middle Aged
  • Occupational Diseases*
  • Occupational Exposure*
  • Scleroderma, Localized / chemically induced
  • Scleroderma, Localized / epidemiology
  • Scleroderma, Localized / etiology*
  • Scleroderma, Systemic / chemically induced
  • Scleroderma, Systemic / epidemiology
  • Scleroderma, Systemic / etiology*
  • Silicon Dioxide / adverse effects
  • Solvents / adverse effects
  • Vibration / adverse effects
  • Vinyl Chloride / adverse effects


  • Air Pollutants, Occupational
  • Epoxy Resins
  • Hydrocarbons, Chlorinated
  • Solvents
  • Silicon Dioxide
  • Vinyl Chloride