Hormonal profiles in women with breast cancer

Obstet Gynecol Clin North Am. 1994 Dec;21(4):751-72.

Abstract

The literature findings on endogenous hormonal profiles in women with breast cancer are reviewed in detail. It is concluded that four sets of findings are valid: (1) diminished adrenal androgen production, probably genetic, in women with premenopausal breast cancer; (2) ovarian dysfunction (luteal inadequacy plus increased testosterone production) in breast cancer at all ages; (3) increased 16 alpha-hydroxylation of estradiol in breast cancer at all ages; and (4) evidence that prolactin is a permissive risk factor for breast cancer, and that the pregnancy-induced decrease in prolactin levels may account for the protective effect of early pregnancy against breast cancer.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Androgens / physiology
  • Animals
  • Anovulation
  • Breast Neoplasms / complications
  • Breast Neoplasms / physiopathology*
  • Child
  • Estradiol / physiology
  • Estriol / physiology
  • Estrone / physiology
  • Female
  • Hormones / physiology*
  • Humans
  • Luteal Phase
  • Luteinizing Hormone / metabolism
  • Melatonin / physiology
  • Middle Aged
  • Progesterone / physiology
  • Prolactin / physiology
  • Steroid 16-alpha-Hydroxylase
  • Thyroid Diseases / complications

Substances

  • Androgens
  • Hormones
  • Estrone
  • Progesterone
  • Estradiol
  • Prolactin
  • Luteinizing Hormone
  • Steroid 16-alpha-Hydroxylase
  • Estriol
  • Melatonin