Beta-lactam antibiotics alone or in combination with gentamicin for therapy of gram-negative bacillary infections in neutropenic patients

Am J Med Sci. 1976 Mar-Apr;271(2):179-86. doi: 10.1097/00000441-197603000-00006.

Abstract

This study was initiated to determine whether antibiotic combinations are superior to single antibiotics for the treatment of gram-negative bacillary infections in neutropenic patients. Twenty-six patients with Pseudomonas and Proteus infections received either carbenicillin or carbenicillin, plus gentamicin. The cure rates were 83 and 93 per cent, respectively. Twenty-three patients with infections caused by other gram-negative bacilli received either cephalothin plus gentamicin. The cure rates were 64 and 67 per cent, respectively. Superinfection occurred in 26 per cent of the patients who received a single antibiotic compared to 15 per cent of the patients who received a combination. Four of the 26 patients who received gentamicin developed transient azotemia. Combination therapy may be superior to single antibiotic therapy, but this study demonstrated no statistically significant differences.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Agranulocytosis / complications*
  • Bacterial Infections / complications
  • Bacterial Infections / drug therapy*
  • Carbenicillin / therapeutic use*
  • Cephalothin / therapeutic use*
  • Clinical Trials as Topic
  • Drug Evaluation
  • Drug Therapy, Combination
  • Female
  • Gentamicins / therapeutic use*
  • Humans
  • Male
  • Middle Aged
  • Neoplasms / complications
  • Neutropenia / complications*
  • Neutrophils
  • Proteus Infections / drug therapy
  • Pseudomonas Infections / drug therapy

Substances

  • Gentamicins
  • Carbenicillin
  • Cephalothin