The role of cooked food mutagens as possible etiological agents in human cancer. A critical appraisal of recent epidemiological investigations

Rev Epidemiol Sante Publique. 1995;43(2):147-61.

Abstract

The paper reviews the epidemiological studies that investigate the relationships between dietary protein intake and the risk of some cancer and that have been published since 1980. A comparison of these reports is complicated because of many confounding factors that could obscure the conclusions (e.g. choice of controls) and because it is difficult to distinguish the consumption of fat from that of animal proteins. The 75 examined publications deal with the influence of food intake on different cancers: colo-rectal (42), stomach (8), breast (7), ovarian (4), endometrium (3), prostate (4), pancreas (2), urothelium (1), bladder (2), brain (1), lymphoma (1). From these studies in parallel with information from other sources, it is concluded that pyrolysis products generated by heat treatment of protein-rich food could be responsible factors for, at least, colo-rectal cancer.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Breast Neoplasms / epidemiology
  • Breast Neoplasms / etiology
  • Case-Control Studies
  • Cohort Studies
  • Colorectal Neoplasms / epidemiology
  • Colorectal Neoplasms / etiology
  • Diet
  • Dietary Fats
  • Dietary Proteins
  • Endometrial Neoplasms / epidemiology
  • Endometrial Neoplasms / etiology
  • Female
  • Food*
  • Hot Temperature*
  • Humans
  • Male
  • Mutagens*
  • Neoplasms / epidemiology
  • Neoplasms / etiology*
  • Ovarian Neoplasms / epidemiology
  • Ovarian Neoplasms / etiology
  • Prospective Studies
  • Prostatic Neoplasms / epidemiology
  • Prostatic Neoplasms / etiology
  • Risk Factors
  • Stomach Neoplasms / epidemiology
  • Stomach Neoplasms / etiology

Substances

  • Dietary Fats
  • Dietary Proteins
  • Mutagens