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Review
, 11 (4), 132-6

Trans-splicing and Polycistronic Transcription in Caenorhabditis Elegans

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Review

Trans-splicing and Polycistronic Transcription in Caenorhabditis Elegans

T Blumenthal. Trends Genet.

Abstract

Caenorhabditis elegans engages in three distinct versions of nuclear pre-mRNA splicing: cis-splicing of introns and two kinds of trans-splicing that result in the addition of two different spliced leaders onto mRNAs. One leader (SL1) is used near the 5' ends of pre-mRNAs while the other (SL2) is used at internal trans-splice sites of polycistronic pre-mRNAs. Here, I consider how these three types of splicing event are faithfully carried out.

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