SPECT imaging of gliomas with Thallium-201 and Technetium-99m-HMPAO

Acta Neurol Scand. 1995 Jan;91(1):66-70. doi: 10.1111/j.1600-0404.1995.tb05846.x.


Sequential Thallium-201 and Technetium-99m-HMPAO SPECT images were obtained from 7 patients with high-grade gliomas and 5 patients with low-grade gliomas. The histo-pathological tumor-type was verified from either biopsy specimens or resected tissue from surgery. There was an intense uptake of Thallium-201 in all high-grade gliomas. Compared to the contralateral hemisphere the mean uptake was 4.6 times higher. Low-grade gliomas showed only a marginally increased Thallium-201 uptake (1.4 times). No overlap existed between the two groups. There was no correlation between Technetium-99m-HMPAO uptake and tumor type. Thallium-201 appears to be a promising radiopharmaceutical for differentiating high- and low-grade gliomas, whereas Technetium-99m-HMPAO is not.

Publication types

  • Case Reports
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Brain / blood supply
  • Brain / diagnostic imaging*
  • Brain / pathology
  • Brain Neoplasms / diagnostic imaging*
  • Brain Neoplasms / pathology
  • Female
  • Functional Laterality
  • Glioma / diagnostic imaging*
  • Glioma / pathology
  • Humans
  • Male
  • Middle Aged
  • Regional Blood Flow
  • Technetium*
  • Thallium*
  • Tomography, Emission-Computed, Single-Photon*


  • Technetium
  • Thallium