The topographic distribution of brain atrophy in cortical Lewy body disease: comparison with Alzheimer's disease

Acta Neuropathol. 1995;89(2):178-83. doi: 10.1007/BF00296363.


The topographic distribution of brain atrophy was quantified by image analysis of fixed coronal brain slices from four patients dying with cortical Lewy body disease (CLBD) all with Alzheimer-type pathology and compared to that in four other patients of similar age and gender dying with Alzheimer's disease (AD) alone. The pattern of atrophy in CLBD (+AD) was broadly similar to that in AD alone, suggesting that tissue loss was due mostly to parallel Alzheimer-type pathological changes and that the presence of Lewy bodies in cortical and subcortical neurons contributed little, if anything, to the overall degree of atrophy.

MeSH terms

  • Aged
  • Alzheimer Disease / pathology*
  • Atrophy
  • Autopsy
  • Brain / pathology*
  • Female
  • Frontal Lobe / pathology
  • Hippocampus / pathology
  • Humans
  • Male
  • Middle Aged
  • Parietal Lobe / pathology
  • Parkinson Disease / pathology*
  • Temporal Lobe / pathology