Abstract
The relationship between the response to chemotherapy with cyclophosphamide, epirubicin and fluorouracil as well as the time to progression of metastasised breast cancer and DNA ploidy and S-phase fraction (SPF) of primary tumours was examined using paraffin-embedded tumour tissue from 81 patients. The response to chemotherapy was significantly better in patients with tumours with a high SPF, and in addition the time to progression was longer in the high-SPF group. There was no significant difference when the DNA ploidy and response to treatment were compared.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Bone Neoplasms / secondary
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Breast Neoplasms / drug therapy*
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Breast Neoplasms / genetics*
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Breast Neoplasms / pathology
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Cyclophosphamide / administration & dosage
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DNA, Neoplasm / genetics*
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Drug Administration Schedule
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Epirubicin / administration & dosage
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Female
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Fluorouracil / administration & dosage
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Humans
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Middle Aged
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Ploidies*
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Predictive Value of Tests
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S Phase / physiology*
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Soft Tissue Neoplasms / secondary
Substances
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DNA, Neoplasm
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Epirubicin
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Cyclophosphamide
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Fluorouracil