Peptide motifs of HLA-B51, -B52 and -B78 molecules, and implications for Behćet's disease

Int Immunol. 1995 Feb;7(2):223-8. doi: 10.1093/intimm/7.2.223.


Here we report peptide motifs of five HLA-B molecules, B*5101, B*5102, B*5103 B*5201 and B*7801. Motifs were obtained by pool sequencing of natural ligands eluted from the respective molecules expressed in C1R cells upon transfection. A number of individual ligands that could be sequenced confirmed the motifs. All five HLA-B molecules belong to the HLA-B5, B35-cross-reactive group and are closely related as indicated by similar sequences. B51 and B52 are associated with Bw4, whereas B78 is associated with Bw6. One of the HLA-B molecules investigated here, HLA-B*5101, is associated with Behçet's disease, a multisystemic inflammatory disease affecting various organs. This disease is especially frequent among the Japanese population. The subtle differences between the peptide motifs of B*5101 as compared with the motifs of the four other closely related but not disease-associated molecules could shed light on the nature of the HLA-association of Behçet's disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Behcet Syndrome / immunology*
  • Cells, Cultured
  • Flow Cytometry
  • HLA-B Antigens / chemistry*
  • HLA-B51 Antigen
  • HLA-B52 Antigen
  • Humans
  • Molecular Sequence Data
  • Peptide Fragments / chemistry
  • Sequence Homology, Amino Acid
  • Transfection / genetics


  • HLA-B Antigens
  • HLA-B51 Antigen
  • HLA-B52 Antigen
  • Peptide Fragments