Abstract
Following oral administration of (-)-epigallocatechin gallate to rats, the presence of (-)-epigallocatechin gallate was examined in the portal blood. A compound present in the blood was identified as (-)-epigallocatechin gallate by HPLC and mass spectrometry analysis. The results clearly demonstrate that (-)-epigallocatechin gallate is absorbed, at least in part, into rat portal blood.
MeSH terms
-
Absorption
-
Administration, Oral
-
Animals
-
Antineoplastic Agents, Phytogenic / administration & dosage
-
Antineoplastic Agents, Phytogenic / blood
-
Antineoplastic Agents, Phytogenic / pharmacokinetics*
-
Catechin / administration & dosage
-
Catechin / analogs & derivatives*
-
Catechin / blood
-
Catechin / pharmacokinetics
-
Chromatography, High Pressure Liquid
-
Male
-
Portal Vein / metabolism
-
Rats
-
Rats, Wistar
-
Spectrometry, Mass, Fast Atom Bombardment
-
Spectrophotometry, Ultraviolet
Substances
-
Antineoplastic Agents, Phytogenic
-
Catechin
-
epigallocatechin gallate