Absorption of (-)-epigallocatechin gallate into rat portal vein

Biol Pharm Bull. 1995 Jan;18(1):190-1. doi: 10.1248/bpb.18.190.

Abstract

Following oral administration of (-)-epigallocatechin gallate to rats, the presence of (-)-epigallocatechin gallate was examined in the portal blood. A compound present in the blood was identified as (-)-epigallocatechin gallate by HPLC and mass spectrometry analysis. The results clearly demonstrate that (-)-epigallocatechin gallate is absorbed, at least in part, into rat portal blood.

MeSH terms

  • Absorption
  • Administration, Oral
  • Animals
  • Antineoplastic Agents, Phytogenic / administration & dosage
  • Antineoplastic Agents, Phytogenic / blood
  • Antineoplastic Agents, Phytogenic / pharmacokinetics*
  • Catechin / administration & dosage
  • Catechin / analogs & derivatives*
  • Catechin / blood
  • Catechin / pharmacokinetics
  • Chromatography, High Pressure Liquid
  • Male
  • Portal Vein / metabolism
  • Rats
  • Rats, Wistar
  • Spectrometry, Mass, Fast Atom Bombardment
  • Spectrophotometry, Ultraviolet

Substances

  • Antineoplastic Agents, Phytogenic
  • Catechin
  • epigallocatechin gallate