Circulating interleukin-6 levels in patients with bronchial asthma

Am J Respir Crit Care Med. 1995 May;151(5):1354-8. doi: 10.1164/ajrccm.151.5.7735584.


Circulating interleukin-6 (IL-6) levels were determined using a sensitive enzyme immunoassay in adults with asthma in stable condition during naturally occurring attacks and before and after allergen inhalation tests. IL-6 was significantly elevated even in asymptomatic asthmatic subjects (n = 17) compared with normal control subjects (n = 17). During naturally occurring asthmatic attacks, serum IL-6 levels were significantly elevated in comparison with those in a symptom-free condition (4 wk interval; n = 8, p < 0.01). No significant difference was observed in serum IL-6 levels obtained from control asymptomatic asthmatic subjects during the period (n = 10). There was a significant elevation in circulating IL-6 levels in eight asthmatic patients following inhalation of allergen but not methacholine. These results suggest that IL-6 is involved in the pathophysiology of bronchial asthma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Allergens / administration & dosage
  • Asthma / blood*
  • Asthma / physiopathology
  • Bronchial Provocation Tests
  • Female
  • Forced Expiratory Volume
  • Humans
  • Interleukin-6 / blood*
  • Male
  • Methacholine Chloride
  • Middle Aged
  • Peak Expiratory Flow Rate


  • Allergens
  • Interleukin-6
  • Methacholine Chloride