The role of tobacco in penile carcinoma

Br J Urol. 1995 Mar;75(3):375-7. doi: 10.1111/j.1464-410x.1995.tb07352.x.


Objective: To study the role of tobacco in squamous cell carcinoma of the penis.

Subjects and methods: The use of tobacco in the form of cigarettes, chewing tobacco and snuff was studied in a total of 503 patients and age-matched controls.

Results: By multivariate analysis, a significant association was found between smoking (P = 0.002) or chewing tobacco (P < 0.001) and the use of snuff (P = 0.004) in patients with penile carcinoma as compared with controls. A dose-response relationship was observed for both smoking and chewing.

Conclusions: The use of tobacco is a significant risk factor for penile carcinoma, and the use of more than one form of tobacco increases this risk.

MeSH terms

  • Carcinoma, Squamous Cell / etiology*
  • Humans
  • Logistic Models
  • Male
  • Multivariate Analysis
  • Penile Neoplasms / etiology*
  • Phimosis / complications
  • Plants, Toxic*
  • Random Allocation
  • Risk Factors
  • Smoking / adverse effects*
  • Tobacco, Smokeless / adverse effects*