Gene alterations in intestinal metaplasia and gastric cancer

Eur J Gastroenterol Hepatol. 1994 Dec:6 Suppl 1:S97-102.


Purpose: To review genetic alterations in precancerous lesions and adenocarcinoma of the stomach.

Results: Telomere reduction, tpr-met oncogenic rearrangement, overexpression of cripto, p53 mutations, adenomatous polyposis coli gene mutations and K-ras mutations, which are frequently associated with the well differentiated or intestinal type of stomach cancer, were found in intestinal metaplasia and adenoma of the stomach.

Conclusions: Among these genetic alterations, reduction of telomere repeat arrays might be the initial step in the genetic instability of stomach carcinogenesis. Some of the well differentiated type stomach cancers may develop by an accumulation of multiple gene changes similar to those of colorectal cancer.

Publication types

  • Review

MeSH terms

  • Base Sequence
  • Biomarkers, Tumor / analysis
  • Biomarkers, Tumor / genetics*
  • Epidermal Growth Factor*
  • GPI-Linked Proteins
  • Gene Expression
  • Genes, Tumor Suppressor / genetics
  • Humans
  • Immunohistochemistry
  • Intercellular Signaling Peptides and Proteins
  • Intestines / pathology
  • Membrane Glycoproteins*
  • Metaplasia / genetics
  • Molecular Sequence Data
  • Neoplasm Proteins / analysis
  • Neoplasm Proteins / genetics*
  • Oncogenes / genetics*
  • Precancerous Conditions / genetics*
  • Precancerous Conditions / pathology
  • Stomach Neoplasms / genetics*
  • Stomach Neoplasms / pathology
  • Telomere


  • Biomarkers, Tumor
  • GPI-Linked Proteins
  • Intercellular Signaling Peptides and Proteins
  • Membrane Glycoproteins
  • Neoplasm Proteins
  • TDGF1 protein, human
  • Epidermal Growth Factor