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, 81 (2), 269-78

Genes Involved in Sister Chromatid Separation Are Needed for B-type Cyclin Proteolysis in Budding Yeast

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Genes Involved in Sister Chromatid Separation Are Needed for B-type Cyclin Proteolysis in Budding Yeast

S Irniger et al. Cell.

Erratum in

  • Cell 1998 May 1;93(3):487

Abstract

B-type cyclin destruction is necessary for exit from mitosis and the initiation of a new cell cycle. Through the isolation of mutants, we have identified three essential yeast genes, CDC16, CDC23, and CSE1, which are required for proteolysis of the B-type cyclin CLB2 but not of other unstable proteins. cdc23-1 mutants are defective in both entering and exiting anaphase. Their failure to exit anaphase can be explained by defective cyclin proteolysis. CDC23 is required at the metaphase/anaphase transition to separate sister chromatids, and we speculate that it might promote proteolysis of proteins that hold sister chromatids together. Proteolysis of CLB2 is initiated in early anaphase, but a fraction of CLB2 remains stable until anaphase is complete.

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