Evolutionary conservation of a microsatellite in the Wilms tumour (WT) gene: mapping in sheep and cattle

Cytogenet Cell Genet. 1995;70(1-2):112-5. doi: 10.1159/000134074.

Abstract

A microsatellite in the WT (Wilms tumour) gene is shown to be evolutionarily conserved in a range of mammals. The microsatellite was monomorphic in pig and two alleles have been found in goat. In cattle, a one-base size polymorphism has been discovered outside the microsatellite. WT was genetically mapped to bovine chromosome 15 and to sheep chromosome 15 by synteny mapping. Conservation of chromosome segments of HSA11 and BTA15 is discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Cattle
  • Chromosome Mapping / veterinary
  • Conserved Sequence / genetics*
  • DNA, Satellite / genetics*
  • Genes, Wilms Tumor / genetics*
  • Genetic Linkage
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Sheep

Substances

  • DNA, Satellite

Associated data

  • GENBANK/S77337