Two categories of synovial sarcoma defined by divergent chromosome translocation breakpoints in Xp11.2, with implications for the histologic sub-classification of synovial sarcoma

P J Renwick; B R Reeves; P Dal Cin; C D Fletcher; H Kempski; R Sciot; B Kazmierczak; K Jani; H Sonobe; J C Knight

doi:10.1159/000133992

Two categories of synovial sarcoma defined by divergent chromosome translocation breakpoints in Xp11.2, with implications for the histologic sub-classification of synovial sarcoma

Cytogenet Cell Genet. 1995;70(1-2):58-63. doi: 10.1159/000133992.

Authors

P J Renwick¹, B R Reeves, P Dal Cin, C D Fletcher, H Kempski, R Sciot, B Kazmierczak, K Jani, H Sonobe, J C Knight

Affiliation

¹ Department of Histopathology, U.M.D.S. St Thomas' Hospital, London, UK.

PMID: 7736791
DOI: 10.1159/000133992

Abstract

Molecular analysis of a new series of synovial sarcomas confirms that t(X;18)(p11.2;q11.2) breakpoints occur at two distinct regions on Xp designated SS1 and SS2. Breakpoint position correlates with tumor phenotype. Monophasic tumors with no evidence of glandular components have breakpoints within the SS2 region in Xp11.21, and biphasic tumors with a focal poorly differentiated or extensive glandular structure have breakpoints within the SS1 region in Xp11.23.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Female
Humans
In Situ Hybridization, Fluorescence
Karyotyping
Male
Middle Aged
Sarcoma, Synovial / classification
Sarcoma, Synovial / genetics*
Sarcoma, Synovial / pathology
Translocation, Genetic*
Tumor Cells, Cultured
X Chromosome*