Human gp130 transducer chain gene (IL6ST) is localized to chromosome band 5q11 and possesses a pseudogene on chromosome band 17p11

Cytogenet Cell Genet. 1995;70(1-2):64-7. doi: 10.1159/000133993.

Abstract

Human gp130 (IL6ST) is one of the most widely used chains of the cytokine receptor family. Indeed, it is involved in signal transduction of interleukin-6, interleukin-11, leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor. In a previous report, IL6ST was assigned to chromosomes 5 and 17. Here we specify the chromosomal sublocalization of IL6ST and show that the sequence detected on 17p11 corresponds, in fact, to a nontranscribed pseudogene, whereas the active gene is located at chromosome band 5q11.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, CD*
  • Base Sequence
  • Chromosomes, Human, Pair 17*
  • Chromosomes, Human, Pair 5*
  • Cytokine Receptor gp130
  • Humans
  • In Situ Hybridization, Fluorescence
  • Membrane Glycoproteins / genetics*
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Polymorphism, Single-Stranded Conformational
  • Pseudogenes / genetics*

Substances

  • Antigens, CD
  • IL6ST protein, human
  • Membrane Glycoproteins
  • Cytokine Receptor gp130